Measuring Response to Antiplatelet Therapy- Rapid.Easy.Proven
VerifyNow is a rapid, simple and accurate system for measuring individual response to every major antiplatelet medication, including aspirin, Plavix®, ReoPro® and Integrilin®.
Backed by clinical training programs and a highly responsive customer support team, it provides a simple and accurate tool to help guide treatment decisions, allowing clinicians to make platelet function assessment a routine component of care for patients receiving antiplatelet agents.
VerifyNow Aspirin Assay Studies have shown response to aspirin therapy varies widely among patients,1,2 and up to one-fourth of patients fail to respond, making them two to three times more likely to have a major heart attack or stroke.3 Because aspirin prevents platelet activation by binding to the COX-1 enzyme and preventing the conversion of arachidonic acid to thromboxane A22, the VerifyNow Aspirin Assay utilizes arachidonic acid as the agonist to measure platelet function along this pathway.
VerifyNow P2Y12 Assay Up to 30% of all patients taking Plavix (clopidogrel) do not receive the anticipated antiplatelet effect4,6 and may be sub-therapeutic or unnecessarily delayed from surgery. Since thienopyridines such as Plavix block the P2Y12 ADP binding site, the VerifyNow P2Y12 Assay uses ADP as an agonist to induce platelet activation and ascertain the level of impairment. It also incorporates a second channel containing thrombin receptor agonists to approximate an absolute baseline function without the need for patients to discontinue medication. VerifyNow IIb/IIIa Assay Patients vary widely in their response to weight-based dosing of fast-acting and powerful GP IIb/IIIa inhibitors, such as ReoPro and Integrilin, that prevent platelet aggregation by blocking platelets from binding to brinogen. In order to assess this response, the VerifyNow IIb/IIIa Assay uses a thrombin receptor activating peptide as an agonist to maximally stimulate platelets and determine their level of function within two minutes from time of sample collection.