Point-of-care (POC) - guided therapy using thromboelastometry ( ROTEM) and Multiplate® analyzer significantly reduces patient exposure to allogenic blood products avoiding unnecessary blood products costs and saving additional costs by reducing intensive care unit and hospital stay time.
Multiplate Platelet Function Testing Benefits
High sensitivity for platelet disorders and other causes of platelet dysfunction
Multiplate is highly sensitive for:
The detection and differentiation of platelet disorders which are based on defined receptor defects like Glanzmann thrombasthenia, Bernard-Soulier syndrome, and ADP receptor defects.
The monitoring of platelet function inhibitors Aspirin®, clopidogrel and prasugrel.
The determination of platelet dysfunction before invasive procedures and the support of improved hemostatic management in bleeding patients.
Von Willebrand disease (comparable to optical aggregometry).
Clinical uses of platelet function testing
Detection of response / non-response to therapy using aspirin, clopidogrel, prasugrel, glycoprotein (Gp)IIb/IIIa-antagonists and/or other antiplatelet drugs
Identification of high platelet reactivity (HPR)
Preoperative evaluation of platelet function
Verification or exclusion of drug-induced or disease-related platelet function disorders
Bleeding risk stratification
Laboratory & Research Applications
Detection of heritable or acquired platelet disorders
Monitoring of anti-platelet therapies
Testing for heparin-induced thrombocytopenia
Assessment of drug effects on platelet function and drug to drug interactions in pharmacological research
Analysis of platelet function of mice, rats, dogs and other animal species
Patients undergoing PCI depend heavily on the antiplatelet treatment with P2Y12-inhibitors. Clopidogrel generics are cheap and safe drugs with great response variability whereas more potent prasugrel and ticagrelor platelet inhibitors are expensive and increase bleeding risk.
Platelet Function Testing (PFT) with Multiplate® may allow for a cost-effective personalized treatment where adequate responders to clopidogrel could be treated with the generic drug, whereas prasugrel and ticagrelor could be reserved for the clopidogrel low-responders.
Since the drug-related costs make a significant part, whereas the costs of Multiplate test are negligible in this scenario, PFT-guided approach may lead to more safety for patients and cost savings for the hospital management as well as the health insurance system. Additional cost benefit arises from the savings of the cost of bleeding treatment.