Fibrinogen Calculator

The FibrinogenCalculator is an educational tool for healthcare professionals only to provide information on fibrinogen treatment and dosing options on the  FIB-test A5 results on the ClotPro.
 

Enter ClotPro  FIB-Test (A5) Results below

 
  1. If IN-test CT < 200 s, then NO Heparin or Protamine effect

  2. If IN-test CT AND HI-test CT > 260 s, then Protamine effect: Wait 20 mins, then repeat

  3. If IN-test CT > 200 s, then calculate ratio (IN-test CT / HI-test CT)

 Input IN-test CT >>>>> 
 Input HI-test CT >>>>> 
This calculator is intended for medical education only.  The user agrees that use is at their own risk.
References:

1. Rapid disappearance of protamine in adults undergoing cardiac operation with cardiopulmonary bypass. Butterworth et al. Ann Thorac Surg 2002;74:1589-1595

2. Mochizuku T, Olsen P, Szlam F, Ramsay J & Levy J. Protamine reversal of Heparin Affects platelet aggregation and activated clotting time after cardiopulmonary bypass. Anaesthesia and analgesia. Vol 88 Issue 4 pp 781-785

3. Hoenicka M, Rupp P, Muller-Eising K, Deininger S, Kunert A, Liebold A, et al. Anticoagulation management during multivessel coronary artery bypass grafting: a randomized trial comparing individualized heparin management and conventional hemostasis management. J Thromb Haemost 2015;13:1196–206.

4. Can extra protamine eliminate heparin rebound following cardiopulmonary bypass surgery? Teoh et al. J Thorac Cardiovasc Surg 2004;128:211-219

5. Detection of Protamine and Heparin After Termination of Cardiopulmonary Bypass; Mittermayr M, Velik-Salchner C, Stalzer B, Margreiter J, Klingler A, Streif W, Fries D, Innerhofer P. Anesth Analg. 2009 Mar;108(3):743-50.