DOASENSE | DOAC Urine Testing | Haemoview Diagnostics

The Direct  Oral Anticolagulant Sensing urine  dipstick allows a simple and fast diagnosis of exclusion for the question whether a patient still has effects of a DOAC medication. 

It can differentiate between factor Xa and thrombin inhibitors, thereby recording all DOAC medicines currently available on the market. 

 

The application is analogous to that of a urine test strip and the result can be read visually after 10 minutes - faster and cheaper than a quantitative laboratory test.

DOAC Dipstick
 

FEATURES & BENEFITS

The determination of DOACs has long been limited to blood sampling approaches, with all their potential limitations, and a rapid assessment of the anticoagulant effect of non-vitamin K antagonist oral anticoagulants (Direct Oral AntiCoagulants – DOACs) by point-of-care testing (POCT) so far has been an unmet clinical need.

DOASENSE offers products for specific testing for DOACs in urine. Tests which are easy to use and easy to interpret, reproducible, and patient friendly.

Typical clinical scenarios where testing for specific DOACs can be of value

 

    • Stroke (e.g. before thrombolytic therapy)

    • Trauma

    • Emergency procedures

    • Evaluating for venous thromboembolism

    • Spontaneous hemorrhage

    • General surgery or invasive procedures

    • Other situations where medication history may not available

 

In each of these situations the objective is establishing the absence of DOACs in the patient prior to procedure.

By its rapid, qualitative point-of-care testing, use of the DOAC Dipstick can support medical decision-making and help avoiding uncontrolled, potentially fatal bleeding, e.g. in emergency care situations or in surgical interventions.

 

How it works

DOAC Dipstick is a diagnostic urine test strip, which is intended for qualitative detection of the absence or presence of direct oral anticoagulants (DOACs: Dabigatran, Apixaban, Edoxaban and Rivaroxaban) in human urine by visual identification of colors.

DOACs are excreted to a large extent into urine by glomerular filtration and a urine-based test can provide greater accuracy than a blood test, as there are no adversely interacting proteins or blood cells. Thus, for our urine-based DOAC Dipstick test a high sensitivity and specificity has been demonstrated (see below).

 

 

The test product allows to identify the absence or presence of:

  • Direct oral Thrombin inhibitors  (Dabigatran - pad #4)

  • Direct oral Factor Xa inhibitors  (Apixaban, Edoxaban and Rivaroxaban - pad #3)

  • Urine color  (for avoiding that dark urine colors impact the DOAC test results - pad #2)

  • Creatinine  (for avoiding that renal insufficiencies impact the DOAC test results - pad #1)

by means of color changes based on a chemical reaction.

Results are ready after 10 min and are obtained by color identification with the naked eye or with the DOASENSE Reader:

Product Details

Specially developed accessories complete the first suite of CE-marked products for rapid point-of-care DOAC testing

 

  • DOAC Dipstick

    • The first POCT for both types of DOACs
      (Visual analysis, or use with DOASENSE Reader

  • DOASENSE Control Urines

    • are specially designed reference substances to support your quality assurance needs

  • DOASENSE Reader

    • Optional photometric evaluation of DOAC Dipstick with qualitative results (screen, printer, LIS interface)

 

Clinical Use

By its rapid, qualitative point-of-care testing, use of the DOAC Dipstick can support medical decision-making and help avoiding uncontrolled, potentially fatal bleeding, e.g. in emergency care situations or in surgical interventions.

 

DOACs are excreted to a large extent into urine by glomerular filtration and a urine-based test can provide greater accuracy than a blood test, as there are no adversely interacting proteins or blood cells.

List of Recent Publications

  • Harenberg J, Schreiner H, Hetjens S, Weiss C.:
    Detecting Anti-IIa and Anti-Xa Direct Oral Anticoagulant (DOAC) Agents in Urine using a DOAC Dipstick.
    Semin Thromb Hemost 2019; 45: 275–284
    [Free open access download HERE]

  • Robert C. Gosselin, Dorothy M. Adcock, Shannon M. Bates, Jonathan Douxfils, Emmanuel J. Favaloro, Isabelle Gouin-Thibault, Cecilia Guillermo, Yohko Kawai, Edelgard Lindhoff-Last, Steve Kitchen:
    International Council for Standardization in Haematology (ICSH) Recommendations for Laboratory Measurement of Direct Oral Anticoagulants
    Thromb Haemost 2018; 118(3): 437-450  [ICSH Guidelines]

  • J. Harenberg, U. Warttinger, S. Hetjens, R. Schreiner, C. Giese, H.-J. Roth, R. Krämer, C. Weiss:
    Reliability and validity of point-of-care tests taken from urine samples of patients on therapy with Apixaban, Rivaroxaban and Dabigatran
    Res Pract Thromb Haemost 2017; 1(Suppl1): PB454
     [Poster]

 

Haemoview Diagnostics

433 Logan Rd Stones Corner

Brisbane,  Queensland  4120

Australia

+61 7 3394 8373

ACN 66 876 163 212

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