An accurate point-of-care test for detecting direct oral anticoagulants
DOASENSE is a single-use, point-of-care urine strip test that is used to detect direct oral anticoagulants (DOACs) in urine.
Qualitative Point-of-Care Strip Test
The use of direct oral anticoagulants (DOACs) is increasing. Unlike warfarin, the effects of DOACs cannot be reliably detected using standard coagulation testing and the rapid reversal of DOACs is complicated.
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Knowing what anticoagulant drug a trauma patient is on and how to reverse it poses a challenge. The ability to rapidly detect and distinguish between the DOACs poses significant benefits in the management of bleeding in trauma patients leading to improved patient outcomes.
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How does Doasense work?
The urine strip test detects DOACs (both factor Xa inhibitors and thrombin inhibitors) based on color-changing chemical reactions that happen on the surface of the DOAC Dipstick test pads. Each dipstick test strip contains 4 test pads to detect:
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direct oral thrombin inhibitors (dabigatran)
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direct oral factor Xa inhibitors (apixaban, edoxaban and rivaroxaban)
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urine colour (validation pad to help exclude abnormal urine colour that can affect results)
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creatinine (validation pad to help exclude impaired renal function that can affect results).
FEATURES & BENEFITS
The determination of DOACs has long been limited to blood sampling approaches, with all their potential limitations, and a rapid assessment of the anticoagulant effect of non-vitamin K antagonist oral anticoagulants (Direct Oral AntiCoagulants – DOACs) by point-of-care testing (POCT) so far has been an unmet clinical need.
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DOASENSE offers products for specific testing for DOACs in urine. Tests that are easy to use and easy to interpret, reproducible, and patient friendly.
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Typical clinical scenarios where testing for specific DOACs can be of value
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Stroke (e.g. before thrombolytic therapy)
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Trauma
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Emergency procedures
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Evaluating for venous thromboembolism
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Spontaneous hemorrhage
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General surgery or invasive procedures
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Other situations where medication history may not available
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In each of these situations the objective is establishing the absence of DOACs in the patient prior to procedure.
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By its rapid, qualitative point-of-care testing, use of the DOAC Dipstick can support medical decision-making and help avoiding uncontrolled, potentially fatal bleeding, e.g. in emergency care situations or in surgical interventions.
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