Multiplate test parameter
The Multiplate analyzer continuously records platelet aggregation. The adhesion and aggregation of platelets onto the Multiplate sensors generate an increase in impedance which is transformed into arbitrary aggregation units and plotted against time.
The most important parameter is the area under the aggregation curve (AUC). It is affected by the total height of the aggregation curve as well as by its slope and is best suited to express the overall platelet activity. Two AUC units are used: U and AU*min (10 AU*min = 1U). The first unit (U) is the preferred one.
Two more parameters are calculated: The aggregation (Agg) is the increase of impedance during analysis. The aggregation is the height of the curve.
The velocity (Vel) is the maximum slope of the aggregation curve.
Unlike other platelet function analyzers Multiplate displays and documents the aggregation tracings which provides the user with a qualitative assessment of platelet function and visual plausibility check.
As seen on the diagrams above two curves are assessed using the two independent sensors in the testcell. The parameters calculated by the software are the mean values of the parameters determined with each curve.