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Grading Fibrinolysis Resistance in Sepsis

For the first time, ICU clinicians have a bedside number that tells them not just how sick their septic patient is, but whether their fibrinolysis is recoverable — and whether today's treatment is working.

Fibrinolysis challenge testing using Clotpro may help identify dynamic fibrinolysis resistance in sepsis.

Fibrinolysis resistance in sepsis.

Related Resources

Customer Brief

Customer brief explaining the grading framework for fibrinolysis resistance.

LinkedIn Post

LinkedIn post introducing this study and inviting discussion.

Journal Article

A grading system of dynamic fibrinolysis resistance in sepsis associates with ICU outcomes
Lucy A. Coupland, Steven A. Frost, Jessica Lin, Nguyen Pham, Eurwin Suryana, Matthew Self, Joanne Chia, Tammy Lam, Zikou Liu, Robert Jaich, Philip J. Crispin, David J. Rabbolini, Ruby H.P. Law, Charithani B. Keragala, Robert L. Medcalf, Anders Aneman
medRxiv 2026.03.25.26349336; doi: https://doi.org/10.64898/2026.03.25.26349336

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