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Clinical Evidence & Infographics

Acute ischaemic stroke, TIA and intracerebral haemorrhage where recent DOAC exposure may affect thrombolysis eligibility or reversal decisions.

DOAC Dipstick Testing in Acute Stroke

Multicentre registry protocol evaluating DOASENSE urine dipsticks against plasma DOAC levels in regional stroke pathways.

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Adult on-pump CABG patients receiving different tranexamic acid schedules

Triple-Bolus Tranexamic Acid in CABG

Observational CABG study comparing triple-bolus TXA with bolus-plus-infusion regimens.

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Trauma, cardiac surgery and obstetric haemorrhage where TXA is used to reduce bleeding and real-time fibrinolysis assessment may be valuable.

Tranexamic Acid, Fibrin Structure and Fibrinolysis

Highlights TXA effect depends on timing and plasminogen/TXA balance within the clot.

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ICU patients on unfractionated heparin, predominantly on ECMO, requiring rapid bedside anticoagulation assessment

ClotPro IN/HI-Test for UFH in Critically Ill Patients

Evaluates the ClotPro IN/HI CT ratio against aPTT and Anti-Xa for UFH monitoring in ICU patients.

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Perspective on unfractionated heparin monitoring across CPB, ECMO and ICU settings.

UFH Monitoring in ECMO and Cardiac Surgery

Re-examines anti-Xa, ACT and viscoelastic assays as reference methods for UFH monitoring in ECMO

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Assessment of impaired fibrinolytic response in septic patients using viscoelastic testing.

Grading Fibrinolysis Resistance in Sepsis

Fibrinolysis challenge testing using Clotpro may help identify dynamic fibrinolysis resistance in sepsis.

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Viscoelastometric interpretation of fibrinolysis patterns in critical illness and bleeding.

Interpreting Low ML in Viscoelastometry

Low maximum lysis values may reflect fibrinolysis resistance rather than fibrinolytic activity.

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High- and intermediate-high-risk pulmonary embolism in ICU.

Personalised Thrombolysis for Acute PE in ICU

Viscoelastometry-guided thrombolysis may support more individualised rtPA dosing and haemostatic monitoring.

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