Precise platelet function testing — from a single drop of whole blood
The Multiplate® system delivers rapid, reliable assessment of platelet function and antiplatelet therapy efficacy. Using small volumes of whole blood, it provides the clinical insights needed to guide treatment decisions — from antiplatelet drug monitoring to bleeding risk assessment.
Clinical Applications
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Blood platelets play a pivotal role in physiological haemostasis. Assessment of platelet function is essential in diagnosing and managing bleeding and clotting disorders, and in monitoring the efficacy of antiplatelet therapies.
Multiplate® is supported by over 1,000 publications describing its methodology and clinical application in platelet testing and haemostasis management.
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Platelet function disorders manifest primarily as bleeding or thrombotic conditions. Multiplate® testing can be applied to the analysis of both inherited and acquired platelet function disorders, supporting accurate diagnosis and treatment planning.
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Multiplate® may be used as a pre-surgical and perioperative tool to predict bleeding risk, monitor the efficacy of prohaemostatic therapies, and determine the therapeutic window after stopping antiplatelet therapy.
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Multiplate® results can be used perioperatively to assess platelet function and integrate into institutional Critical Bleeding Protocols — reducing platelet transfusion rates, minimising transfusion-related complications, and supporting your Patient Blood Management (PBM) program outcomes
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Independant channels
Whole Blood
No sample prep required
Impedence
Aggregation Technology
10
Minutes to results
How does Multiplate work?
Multiplate® uses impedance aggregometry to measure platelet function in whole blood. Each disposable test cell contains multiple electrodes that form two independent sensor units — providing built-in duplicate measurement for increased reliability.
The name Multiplate® reflects this multi-layered design: multiple electrodes per test cell, five independent measurement channels, and multiple test procedures — all working together for a thorough evaluation of platelet function.
Watch: How Multiplate® impedance aggregometry works
Multiplate® analysis is based on activated platelets becoming sticky and adhering to metal sensor wires within the disposable test cell. The analyser detects the resulting changes in electrical impedance as platelets aggregate around the sensors.
Using five independent channels simultaneously, whole blood samples are exposed to various platelet agonists. The system measures each channel's platelet response independently — providing precise insights into platelet function and antiplatelet therapy efficacy across multiple pathways in a single test run.
Multiplate® test agonists and their corresponding platelet activation pathways
Testing Options
Multiplate® offers four validated test options, each targeting a distinct platelet activation pathway — allowing comprehensive assessment of platelet function and antiplatelet therapy monitoring in a single platform.
ADP Test
In the ADP test, platelets are activated by ADP, which triggers several receptors on the platelet surface.
Clopidogrel and related drugs block the P2Y12 receptor, which is believed to be the most important receptor for ADP on the platelet surface.
TRAP Test
In the TRAP test, platelets are activated by TRAP-6, a peptide that mimics thrombin — the most potent platelet activator.
Unlike Aspirin® and clopidogrel, thrombin action is not blocked by standard antiplatelet agents, but is inhibited by GPIIb/IIIa antagonists such as ReoPro®, Aggrastat®, and Integrilin
ASPI Test
In the ASPI test, platelets are activated by arachidonic acid, which is converted by the platelet cyclooxygenase enzyme (COX-1) to the potent platelet agonist thromboxane A2.
Arachidonic acid alone is not a platelet agonist and is the physiological substrate of the platelet COX-1. Therefore, platelet activation in the ASPI test allows very sensitive and specific detection of Aspirin® action.
ADP-HS ( PGE) Test
Prostaglandin E1 (PGE1) is used in combination with the ADP test reagent to enhance sensitivity to platelet function inhibition — particularly for detecting the effect of clopidogrel.
A higher dose of PGE1 can also induce abnormal aggregation, enabling positive control performance
Features & Benefits
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Whole blood testing — no sample processing required
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Results in 10 minutes
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Low blood volumes (300 µl)
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Semi-automated for ease of use
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Internal QC checks to ensure quality results
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Graphical and numeric results for easy interpretation
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Windows-based interface
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LIS/HIS connectivity
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RCPA External Quality Control Programme supported
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Customisable for research use
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Low cost compared to cartridge-based systems
Address
Haemoview Diagnostics
Suite 36 1b/47 Park Road
Milton Qld 4064
Australia
Phone
+61 (0)7 2111 6332
