P2Y12 Inhibitor Administration for Intracranial Stenting Procedures, the Usefulness of Multiplate Monitoring

Platelet function monitoring is essential for evaluating the effectiveness of P2Y12 inhibitors in patients undergoing intracranial stent placement. The literature frequently addresses cases of clopidogrel resistance, referred to as "high on-treatment platelet reactivity," associated with variations in Cyt-P2C19 activity.

When resistance is confirmed, ticagrelor is commonly substituted for thienopyridine to enhance treatment efficacy. Utilizing a platelet function monitoring device during intracranial stenting for cerebral aneurysms can mitigate ischemic complications associated with clopidogrel while minimizing the risk of haemorrhagic events from ticagrelor.

Utilising AUC on the Multiplate rather than percentage inhibition enhances the precision of ticagrelor prescription. For further insights, refer to the article: https://pubmed.ncbi.nlm.nih.gov/40486913/