The ClotPro® is a new generation viscoelastometry analyzer, based on both the original Hartert method and established cup and pin viscoelastometry techniques. In ClotPro® the cup is rotated using an elastic element and the pin is stationary during the measurement.
There is a relative movement of the cup and pin by a angle of about 5°. During the course of the clotting process this relative movement between cup and pin is reduced. This reduction of the relative movement between cup and pin is transformed into the viscoelastic amplitude expressed in mm:
0 mm correspond to maximum relative movement between cup and pin (maximal stretch of the clot)
50 mm correspond to a 50% reduced relative movement between the cup and the pin (the stretch of the clot is halved)
100 mm correspond to no relative movement between cup and pin (normally never happens in blood coagulation)
Clotting Time (CT secs)
Coagulation activation is characterized mainly by the CT (clotting time) parameter, which indicates the time from the start of the measurement until a clot firmness of 2 mm is detected.
The clotting time reflects the clotting factors in the sample and potentially clotting factor inhibitors (e.g. heparin).
Clot Amplitude represents the “clot strength” or clot firmness or clot quality. As the ClotProfile grows, it will go from the green line (CT) to pink, to illustrate a clot is starting to grow, and will then turn blue on when it reaches 20mm in height.
It is affected by fibrin and fibrinogen concentration, platelet count/function, thrombin concentration, factor XIII, and hematocrit /hemodilution
Lysis ( ML%)
Normally in viscoelastometry blood clots are stable and show only a limited (<15% ) reduction of clot firmness after the maximum clot firmness is reached.
Hyperfibrinolysis is detected by analysing the clot lysis index.
The ability to detect and determine the severity of fibrinolysis avoids empirical or inappropriate anti-fibrinolytic therapy.
Interpretation should be performed in a stepwise approach
Results need to be interpreted in the context of the test performed AND the clinical context of the patient