Multiplate | Comprehensive Platelet Function Testing

The Multiplate® provides easy and accurate assessment of platelet function utilising the analysis of whole blood. 

The term Multiplate is derived from the phrase “multiple platelet function analyzer”. Multiple stands for the multiple electrodes in the disposable test cell (4 electrodes form 2 independent sensor units), multiple channels of the instrument (5) as well as multiple test procedures available for a comprehensive assessment of platelet function.

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FEATURES & BENEFITS

A reliable tool for testing platelet function

The Multiplate® system may be used to personalize anti-platelet therapy and / or to stratify bleeding risk and - with small volumes of whole blood.

Blood platelets play a pivotal role in physiological hemostasis. Disorders of platelet function in general manifest most clearly as either as bleedings or thrombotic disorders hence platelet function testing can be utilized in the analysis of inherited and acquired platelet function disorders.

The Multiplate® Analyzer can detect platelet dysfunction and thus may be used to aid in the diagnosis and clinical management of patients with platelet function disorders
 
The Multiplate® Analyzer may also be used as a pre-surgical and/or perioperative tool to aid in the prediction of bleeding and for monitoring the efficacy of various types of prohemostatic therapies. Studies have shown that Multiplate® results, used in conjunction with clinical presentation and additional laboratory markers, may be used to help determine timing of surgery after stopping antiplatelet therapy.

Multiplate® results may also be used to assess platelet function perioperative and could be integrated into institution transfusion algorithm to reduce platelet transfusion rates and hence risks from potential complications of platelet transfusion. Reduced platelet transfusions may also help to reduce costs

 

High sensitivity  for platelet disorders and other causes of platelet dysfunction

Multiplate Platelet Function Testing Benefits

Multiplate is highly sensitive for:

  • The detection and differentiation of platelet disorders which are based on defined receptor defects like Glanzmann thrombasthenia, Bernard-Soulier syndrome, and ADP receptor defects.

  • The monitoring of platelet function inhibitors Aspirin®, clopidogrel and prasugrel.

  • The determination of platelet dysfunction before invasive procedures and the support of improved hemostatic management in bleeding patients.

  • Von Willebrand disease (comparable to optical aggregometry).​

Clinical uses of platelet function testing 

Platelet Activation Receptor Sites
  • Detection of response / non-response to therapy using aspirin, clopidogrel, prasugrel, glycoprotein (Gp)IIb/IIIa-antagonists and/or other antiplatelet drugs

  • Identification of high platelet reactivity (HPR)

  • Preoperative evaluation of platelet function

  • Verification or exclusion of drug-induced or disease-related platelet function disorders

  • Bleeding risk stratification

Laboratory & Research Applications

  • Detection of heritable or acquired platelet disorders

  • Monitoring of anti-platelet therapies

  • Testing for heparin-induced thrombocytopenia

  • Assessment of drug effects on platelet function and drug to drug interactions  in pharmacological research

  • Analysis of platelet function of mice, rats, dogs and other animal species

ASSAYS

ADP test

Assay for the quantitative in vitro determination of platelet function following stimulation of the platelet adenosine diphosphate (ADP) receptors​  such as clopidogrel, prasugrel and other ADP receptor antagonists.

 

ASPI test

Assay for the quantitative in vitro determination of platelet function triggered by arachidonic acid used for monitoring of Aspirin® and other cycloxygenase inhibitors.

TRAP test

The TRAPtest may be used to detect platelet function triggered via the thrombin receptor without triggering fibrin formation,  Sensitive to the action of glycoprotein (Gp) IIb/IIIa receptor antagonists and/or a deficiency of GpIIb/IIIa receptors.

 

Test principle

The principle of Multiplate® analysis is based on the fact that platelets become sticky upon activation and adhere and aggregate onto the metal sensor wires in the Multiplate® test cell.

 

The test cell has a pipetting inlet and a cup portion with the sensor wires which extend into the blood sample. The sensor wires are made of highly conductive copper which are silver-coated.

The test cell is connected to the instrument using a sensor cable and the electrical resistance between the sensor wires is recorded during the test.

 

When activated, platelets adhere to the sensor wires and the electrical resistance between the wires increases.

 

Specifications

  • Whole blood, no sample processing

  • Small sample volume (300 µl)

  • Mini test cells use 175 µl of whole blood; smallest volume requirement for aggregometry testing. Ideal for pediatric platelet research or animal platelet studies.

  • Up to 30 tests per hour

  • Interactive electronic pipetting

  • 5 independent channels for parallel testing

  • Specific and sensitive reagents

  • Standardized test procedures

  • Open system for research applications

  • Windows-based software

  • New tests can be defined in the system software

Haemoview Diagnostics

433 Logan Rd Stones Corner

Brisbane,  Queensland  4120

Australia

+61 7 3394 8373

ACN 66 876 163 212

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